Exposures to blood and other body fluids occur across a wide variety of occupations. Health care workers, emergency response and public safety personnel, and other workers can be exposed to blood through needlestick and other sharps injuries, mucous membrane, and skin exposures. The pathogens of primary concern are the human immunodeficiency virus HIV, hepatitis B virus HBV, and hepatitis C virus HCV. Workers and employers are urged to take advantage of available engineering controls and work practices to prevent exposure to blood and other body fluids.